Anti-Obesity Effects of Onion Extract in Zucker Diabetic Fatty Rats
نویسندگان
چکیده
Anti-obesity effects of onion extract were determined in obesity and diabetes-prone Zucker diabetic fatty rats by measuring the efficacy of markers concerned with diabetes and obesity. Body and adipose tissue weights in 5% of onion extract-fed group were found to be significantly lower than the control group without onion extract. Fasting blood glucose and HOMA-IR levels were also improved, although the serum insulin and leptin levels did not show any remarkable difference. Serum triglyceride and free fatty acid levels in both the 3% and 5%-fed group were found to be reduced compared to the control group. Additionally the feeding of the onion extract increased the glucose tolerance. These results suggest that dietary onion extract is beneficial for improving diabetes by decreasing lipid levels. We also examined differentiation ability of rat white preadipocyte cells using the onion extract and its sulfur-containing components. Cycloalliin, S-methyl-L-cysteine, S-propyl-L-cysteine sulfoxide, dimethyl trisulfide, especially S-methyl-L-cysteine sulfoxide were reported to be effective in inhibiting formation of oil drop in the cells, suggesting that these compounds may be involved in the anti-obesity effect of the onion extract.
منابع مشابه
Purslane extract effects on obesity-induced diabetic rats fed a high-fat diet.
Purslane extract in the form of ethanolic formulation is rich in polyphenols, flavonoids and anthocyanin, w-3 fatty acids and melatonin. The present study was designed to investigate the anti-obesity and anti-diabetic effects of purslane using obese diabetic rats. The rats received either regular diet, high-fat diet or high-fat diet with additional purslane (150 and 300 mg/kg body weight) for 8...
متن کاملA GIP Receptor Agonist Exhibits β-Cell Anti-Apoptotic Actions in Rat Models of Diabetes Resulting in Improved β-Cell Function and Glycemic Control
AIMS The gastrointestinal hormone GIP promotes pancreatic islet function and exerts pro-survival actions on cultured beta-cells. However, GIP also promotes lipogenesis, thus potentially restricting its therapeutic use. The current studies evaluated the effects of a truncated GIP analog, D-Ala(2)-GIP(1-30) (D-GIP(1-30)), on glucose homeostasis and beta-cell mass in rat models of diabetes. MATE...
متن کاملEffect of alcoholic extract of Iranian red onion on diabetic neuropathic pain in streptozotocin-diabetic rats
Introduction: Neuropathic pain is one of the common complications of diabetes mellitus which is caused by impairment in nerve conductivity. The role of flavonoid and polyphenol compounds in treatment of neuropathic pain has been revealed, and extract of onion contains significant amounts of these compounds. The aim of this study was to investigate the effect of alcoholic extract of onion on ...
متن کاملEffects of Alpha-Lipoic Acid on Oxidative Stress and Kinin Receptor Expression in Obese Zucker Diabetic Fatty Rats
OBJECTIVE To investigate the impact of alpha-lipoic acid on superoxide anion production and NADPH oxidase activity as well as on the expression of kinin B1 and B2 receptors in key organs of obese Zucker Diabetic Fatty rats. METHODS Superoxide anion production was measured by lucigenin chemiluminescence. Kinin B1 and B2 receptors expression was measured at protein and mRNA levels by western bl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2012